In this conversation, I discuss long-term use of GLP-1 receptor agonists and what current evidence suggests. We explore potential benefits beyond weight loss, including possible reductions in cardiovascular events and signals for improved kidney and liver health. We also touch on early observations around addictive behaviour, reports of reduced sexual desire in some individuals, and the fact that 10-year data are still limited. This segment examines what we can and cannot infer about cancer risk, including a tentative hint around colorectal incidence, and highlights the very real issue of cost. There is reflection on how widespread use has become, and what that could mean for heart attacks, strokes, kidney and liver disease, and diabetes complications at a population level, as well as the implications for healthy ageing and quality of life. Stream the full episode on YouTube: https://www.youtube.com/watch?v=-Y4h68D40vg Or listen on your favourite podcasting platform: https://theproof.com/how-body-fat-affects-your-metabolic-health-and-risk-of-metabolic-disease-dr-robert-eckel/ Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit https://theproof.com/friends/. • The Proof with Simon Hill - https://theproof.com/podcast/ • Book: The Proof is in the Plants - https://theproof.com/book/ • Apple Podcast - https://podcasts.apple.com/gb/podcast/the-proof-with-simonhill/id1367773989 • Spotify - https://open.spotify.com/show/7bAIJCVgnquxXZuQCdZyTi • Instagram - https://www.instagram.com/theproof/ • Twitter - https://twitter.com/theproof • Facebook - https://www.facebook.com/theproofwithsimonhill • Plant-Based Ferments Guide - https://theproof.com/ferments/ • Two-week meal plan - https://theproof.com/mealplan/ • Plant Performance - https://theproof.com/plant-performance/ • Use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends.

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