Weight Loss Surgeon: The Science of Food Cravings, Hunger & Weight Loss | Dr Terry Simpson | EP#421

Dr Terry Simpson is a bariatric surgeon, virologist by training, and one of the most active science communicators in the medical misinformation space. He has familial hypercholesterolemia, a father and a brother who both died young of heart disease, and he lost 50 pounds on a GLP-1. In this conversation, he takes me through what is actually in the data on GLP-1 medications, statins, ApoB, the Mediterranean diet, COVID, and the loud contrarians who shape so much of what people read online. In this episode we discuss: - How to think about uncertainty in science, and why "con men and religious figures both speak in absolutes" - The Gila monster origin story of GLP-1 medications, and the difference between native and pharmacological GLP-1 - What food noise actually is, and why fibre and probiotics will not replace a weekly injection - Terry's personal experience on tirzepatide: weight loss, sleep apnea, alcohol, testosterone, stress - His case for statins as someone with familial hypercholesterolemia, and an ApoB in the 40s - A defence of Ancel Keys and the Mediterranean diet To connect with Dr Terry Simpson, visit terrysimpson.com for his bio, recipes, and blog, find him on TikTok at @drterrysimpson, on Instagram at @drterrysimpsonmd, on X at @drterrysimpson, and on Substack at @drsimpson. His podcast is The Unfiltered MD. 00:00 Intro 01:19 Why Carnivore and Anti-Vax Are Today's Biggest Health Lies 04:13 Doctors, COVID and the Cost of Speaking Up Online 13:41 How to Spot a Health Huckster 19:29 Will GLP-1 Drugs Make Bariatric Surgery Obsolete 23:09 A Bariatric Surgeon's Personal Decision to Take a GLP-1 Drug 26:39 Willpower Is Not the Problem: What Food Noise Actually Feels Like 36:09 Why Ancel Keys Was Right and Low Carb Got It Wrong 43:07 Mediterranean Diet Results That Stopped a Trial Early 50:55 Are GLP-1 Drugs the Greatest Medical Breakthrough This Century 54:44 The Real Danger of Buying Compounded GLP-1 Drugs Online 01:06:43 BPC-157 and Peptides: Why FDA Guardrails Actually Matter 01:11:59 Familial Hypercholesterolemia, Statins and a Personal Wake Up Call 01:20:04 Inflammation vs. ApoB: What Actually Causes a Heart Attack 01:23:33 CT Angiogram Results and Keto CTA Data Explained 01:31:35 Fish Oil vs. Eating Fish: Why the Supplement Doesn't Replicate the Food 01:35:07 Simon's Plant Based Diet, Seed Oils and Cooking with Olive Oil 01:40:17 The Seed Oil Debate: Are People Just Afraid of Modern Chemistry Subscribe & Connect: - YouTube: https://www.youtube.com/c/TheProofWithSimonHill?sub_confirmation=1 - Apple Podcasts: https://podcasts.apple.com/au/podcast/the-proof-with-simon-hill/id1367773989 This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Head to https://38tera.com/?ref=SIMON and use code THEPROOF for a discount at checkout. 38TERA ships to the United States, Australia, and New Zealand. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on http://im8health.com/. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Truemed Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit Truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars. LMNT Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavors with any purchase at http://drinklmnt.com/SIMON. Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked. LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S. WHOOP WHOOP, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on https://join.whoop.com/simon. WHOOP ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.