The Nutrition Doctor: 40% of weight lost isn't fat! 4 rules for better Ozempic results

Ozempic, Wegovy and Mounjaro can help people lose weight. But what should you eat on GLP-1 drugs to avoid side effects, protect muscle, and maintain results long term? In this episode, Dr Federica Amati, ZOE’s Head Nutritionist and author of The Appetite Reset (https://amzn.to/4blJsLg), explains how these drugs work, why many people struggle with side effects, and why losing weight does not automatically mean better health. You’ll learn why the weight lost may not be fat, why nutrient deficiencies, dehydration and muscle loss can become a risk, and what to eat before, during and after treatment. Federica shares four practical principles to help reduce side effects, protect lean mass, improve diet quality and support long-term health whether you stay on these medications or eventually stop taking them. Millions of people are now using GLP-1 drugs. But if these medications reduce appetite so effectively, how do you make sure your body still gets the nutrients it needs? 🌱 Try our science-backed and tasty wholefood supplement Daily30: https://zoe.com/daily30?utm_medium=zoe_podcast&utm_source=youtube&utm_campaign=d30 🌿Let your gut microbes snack on the ZOE Gut Health Bar | https://zoe.com/snackbar?utm_medium=zoe_podcast&utm_source=youtube&utm_campaign=GHB Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE: https://zoe.com/buymembership?utm_medium=zoe_podcast&utm_source=youtube&utm_campaign=BAU Follow ZOE on Instagram | https://www.instagram.com/zoe/ Timecodes 00:00 The biggest Ozempic mistake people make 03:23 What Ozempic actually does inside your body 06:00 Are Ozempic and Mounjaro really miracle drugs? 10:53 Ozempic vs Wegovy vs Mounjaro: what’s the difference? 11:40 The step almost everyone skips before starting GLP-1s 13:16 Why do some people get worse Ozempic side effects? 15:20 The surprising brain effect changing people’s lives 18:20 The appetite system most people never learn about 21:25 How fibre helps your body make more GLP-1 naturally 24:24 Why ultra-processed foods never keep you full 27:20 Why staying a healthy weight is harder than ever 30:11 The hidden risk nobody mentions when losing weight 32:11 The 4 rules to protect muscle, bones and brain health 34:24 The side effect that can make life feel less enjoyable 35:26 What happens if you stay on Ozempic but never change your diet? 38:16 Can Ozempic cause malnutrition? Warning signs to know 39:35 Why some people suddenly stop craving junk food 41:15 What should you eat before starting Ozempic? 42:50 What should you eat while taking Ozempic? 44:01 Why meal timing matters more than you think 46:25 The eating mistake that triggers nausea and vomiting 47:18 The best protein foods for GLP-1 users 49:15 Can Ozempic cause muscle loss? The protein myth explained 51:40 What should you eat when coming off Ozempic? 53:15 Why some people keep the weight off for years 57:45 Why do most people quit Ozempic within a year? 📚Books by our ZOE Scientists The Food For Life Cookbook | https://amzn.to/4amfIMX Every Body Should Know This by Dr Federica Amati | https://amzn.to/4blJsLg The Appetite Reset by Dr Federica Amati | https://amzn.to/4aBakbR Food For Life by Prof. Tim Spector | https://amzn.to/4amZinu Ferment by Prof. Tim Spector | https://amzn.to/4hU1Df5 Good Mood Food (preorder) by Prof. Tim Spector | https://amzn.to/4l9oXat Free resources from ZOE: Eating for Better Brain Health: Your brain-gut blueprint | https://ZOE.com/brainhealth?utm_medium=zoe_podcast&utm_source=youtube&utm_campaign=betterbrainhealth Live Healthier: Top 10 Tips From ZOE Science & Nutrition | https://zoe.com/freeguide?utm_medium=podcast&utm_source=youtube&utm_campaign=freeguide Gut Guide - For a Healthier Microbiome in Weeks | https://zoe.com/gutguide?utm_medium=podcast&utm_source=youtube&utm_campaign=gutguide Better Breakfast Guide | https://zoe.com/breakfastguide?utm_medium=podcast&utm_source=youtube&utm_campaign=breakfastguide Mentioned in today's episode The Appetite Reset by Dr Federica Amati | https://amzn.to/4aBakbR GLP-1 Discontinuation Among Patients, Diabetes and Endocrinology (2024) | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2819256 How much protein do you need? ZOE’s new guide | https://zoe.com/learn/how-much-protein-do-you-need-zoe-guide Managing Gastrointestinal Adverse Events in Patients Treated with GLP-1s, Journal of Clinical Medicine (2022) | https://pmc.ncbi.nlm.nih.gov/articles/PMC9821052/ Neurological complications following GLP-1 use, BMC Neurology (2025) | https://link.springer.com/article/10.1186/s12883-025-04540-7 Have feedback or a topic you'd like us to cover? Let us know here: https://gf6hx47iu5g.typeform.com/topicsuggestion Episode transcripts are available here: https://zoe.com/learn/category/podcasts