Genital Herpes: Spatiotemporal Battlefield Mapping to In Vitro Modeling & Antiviral Drug Discovery

Genital herpes is a highly prevalent sexually transmitted disease caused by the herpes simplex virus (HSV), with no cure and no vaccine for prevention. We develop and apply various state-of-the-art in situ approaches to gain insights into the protective immunity at the site of HSV manifestation using sequential biopsies from patients with diverse clinical outcomes. Upon completion of this program, attendees should be able to: • Summarize protective immune responses in human genital herpes infection. • Recognize vascularized 3D human skin-on-chip as an in vitro model for HSV research. • Describe the application of 3D bioprinted human skin equivalents for anti-HSV drug discovery. Jia Zhu, PhD Research Professor, Virology Department of Laboratory Medicine & Pathology University of Washington 09/24/25 The University of Washington is committed to ensuring digital accessibility in our services, programs, and activities. If you encounter accessibility barriers using videos found on this channel, please contact UW Video at uwvideo [at] uw [dot] edu.