Malaria remains a global health problem that disproportionately impacts children. Due to rising challenges with current diagnostic strategies, new ways to diagnose malaria are urgently needed. This presentation will highlight ongoing efforts to develop non-invasive breath-based diagnostics for Plasmodium spp. infection. In addition, the presentation will discuss the current methods and challenges with breath-based analyses, as well as efforts to identify the biological origin of human breath metabolites. After viewing this lecture, participants should be able to: 1. -Describe the current epidemiology of malaria 2. -Define the current state of malaria diagnostics 3. -Review the methods and potential for breath-based diagnostic platforms Audrey R. Odon John, MD, PhD, Stanley Plotkin Endowed Chair, Professor and Chief, Infectious Diseases Perelman School of Medicine, University of Pennsylvania The University of Washington is committed to ensuring digital accessibility in our services, programs, and activities. If you encounter accessibility barriers using videos found on this channel, please contact UW Video at uwvideo [at] uw [dot] edu.