Jason Calacanis sits down with three CEOs building at the bleeding edge of the agentic revolution: *Mitesh Agrawal* (Positron AI), *Alex Elias* (Qloo), and *Kash Ali* (TaxGPT). They discuss the rapid rise of **Open Claw**, an open-source platform that is fundamentally changing work by allowing users to create autonomous agents. "Saving 30 minutes a day... that’s like getting three more weeks a year back." "I don't need a technical recruiter today." We explore how autonomous agents are moving beyond "Copilots" to become independent teammates: - *The AI Executive Assistant:* How Mitesh Agrawal uses agents to automate inbox filtering and Slack drafts, recapturing 6% of his year. - *The Hiring Hiatus:* Kash Ali screened 1,000 job applications in two hours with "flawless" accuracy, replacing 40+ hours of manual labor. - *The $1M One-Person Firm:* How AI is solving the shortage of 340,000 accountants by allowing a single person to command an "army of agents". - *Democratizing Luxury:* Scaling the "chauffeur and concierge" experience to everyone through taste-based AI and structured inference. - *Autonomous Media:* A demo of an agent that transcribes, clips, and captions viral content in five minutes, a process that previously took an hour. The agent era is here. Are you building your replicant, or are you being left behind by a 10x more efficient workforce This Week In Startups is made possible by: Notion - https://www.notion.com/twist Quadratic - https://www.Quadratic.ai/twist *Timestamps:* 00:00 Welcome to This Week in AI! 03:17 How are CEO’s using OpenClaw? 09:25 Notion - Notion brings all your notes, docs, and projects into one connected space that just works with AI built right in. Try Notion, with Notion Agent, at notion.com/twist 00:19:09 — Automating the "Great Hiring Hiatus” 00:19:20 Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit [quadratic.ai/twist](https://www.quadratic.ai/twist) to sign up and use the code TWIST to get one free month of their pro tier subscription. 00:27:11 — Saving Independent Film with AI Extras 00:33:04 — Solving the Global Accounting Crisis 00:36:36 — The $1 Million One-Person Tax Advisory 00:43:05 — Demo: The Autonomous Content Clipper 01:07:39 — Micro-Agents vs. "Ultron” 01:10:23 — The Developer, the CEO, and the AI Joke (Outro) Subscribe to This Week in AI on Apple: https://podcasts.apple.com/us/podcast/this-week-in-startups/id315114957 Thanks for watching! 🤖 If you want to stay ahead of the curve on all things AI, make sure to join our community across all platforms: 📩 Get the Weekly Newsletter: https://thisweekinai.ai/ 📺 Subscribe on YouTube: [www.youtube.com/@ThisWeekinAIPodcast](http://www.youtube.com/@ThisWeekinAIPodcast) 📸 Instagram: [www.instagram.com/thisweekinaipodcast](http://www.instagram.com/thisweekinaipodcast) 📱 TikTok: [www.tiktok.com/@thisweekinaipodcast](http://www.tiktok.com/@thisweekinaipodcast) ✖️X: https://x.com/ThisWeeknAI Follow Jason: X: https://twitter.com/Jason LinkedIn: [https://www.linkedin.com/in/jasoncalacanis](https://www.linkedin.com/in/jasoncalacanis/) * Thank you to our partners: 09:25 Notion - Notion brings all your notes, docs, and projects into one connected space that just works with AI built right in. Try Notion, with Notion Agent, at notion.com/twist 00:19:20 Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit [quadratic.ai/twist](https://www.quadratic.ai/twist) to sign up and use the code TWIST to get one free month of their pro tier subscription. Check out all our partner offers: https://partners.launch.co/

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