Hypercoagulable States (Thrombophilia) | Clinical Medicine

Premium Member Resources: https://ninjanerd.org Ninja Nerds! In this lecture, Professor Zach Murphy will present on Hypercoagulable States (Thrombophilia). We will begin by discussing the pathophysiology behind inherited and acquired hypercoagulable conditions, highlighting mechanisms that increase the risk of abnormal clot formation. Key topics include Factor V Leiden mutation, Prothrombin gene mutation, Protein C and S deficiencies, Antithrombin III deficiency, and antiphospholipid antibody syndrome. Next, we will cover the clinical manifestations and complications associated with hypercoagulable states, such as deep vein thrombosis (DVT) and pulmonary embolism (PE). We’ll also differentiate between inherited and acquired causes and discuss high-yield risk factors such as malignancy, surgery, and estrogen therapy. We’ll conclude the lecture with a review of the diagnostic approach, the indications for testing, and management strategies, including anticoagulation and prevention of thrombotic events. This lecture is designed to help students prepare for medical exams like the USMLE and PANCE while reinforcing essential clinical knowledge. Enjoy the lecture and support us below! Table of Contents: 0:00 Lab 0:36 Pathophysiology of Hypercoagulable States 15:50 Causes of Inherited Hypercoagulable States 37:02 Causes of Acquired Hypercoagulable States 58:32 Complications of Hypercoagulable States 1:05:40 Diagnostic Approach to Hypercoagulable States 1:11:19 Treatment Approach of Hypercoagulable States 1:14:55 Treatment of Hypercoagulable States 1:19:12 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #hematology #thrombophilia