Antineoplastic Agents | Clinical Medicine

Premium Member Resources: https://ninjanerd.org Ninja Nerds! In this whiteboard and digital video, Professor Zach Murphy walks you through Antineoplastic Agents in a way that helps you actually understand why these drugs work, where they act, and how to organize them fast when you are studying for exams. We start by building the foundation with cell cycle physiology and regulation, including how cancer cells avoid the resting state and keep pushing forward through growth and DNA synthesis, and how signaling pathways drive cell cycle progression through CDK activity.  Next, we connect core tumor biology to modern therapies by reviewing immune surveillance and angiogenesis, focusing on how tumors exploit checkpoint signaling and VEGF driven blood supply to survive and expand.  From there, we organize chemotherapy into high yield drug classes with clear mechanisms and examples, including antimetabolites, microtubule inhibitors, topoisomerase inhibitors, antitumor antibiotics, and alkylating agents, so you can quickly recognize what each class disrupts during cell division and DNA handling.  We then transition into targeted and immune based therapies, breaking down protein kinase inhibitors, monoclonal antibodies, hormonal therapies, and immune checkpoint inhibitors, with an emphasis on how each category blocks specific growth signaling or immune evasion pathways.  To bring it all together, we map these agents to classic clinical use cases and common regimens across major malignancies, and we finish with the toxicities you must know plus the rescue and protective agents that show up in question stems, including leucovorin, mesna, amifostine, and dexrazoxane.   Enjoy the video, and please support us below! Table of Contents: 0:00 Lab Whiteboard 1:19 Cell Cycle 10:13 Cell Cycle Regulation 22:50 Immune Evasion 28:35 Angiogenesis 31:08 Cell Cycle Inhibitors 40:14 Antimetabolites 1:01:15 Topoisomerase Inhibitors 1:09:21 Microtubule Inhibitors 1:16:49 Antitumor Antibiotics 1:26:43 Alkylating Agents 1:36:25 Protein Kinase Inhibitors 1:45:21 Hormonal Therapy 1:55:31 Monoclonal Antibodies 2:07:59 Immune Checkpoint Inhibitors Digital Presentation 2:17:14 Overview of Antineoplastic Agents and Review 2:53:31 Indications of Chemotherapy Agents 3:06:45 Adverse Effects of Antineoplastic Agents and Chemo Man 3:18:37 Detoxifying Agents Outro 3:24:23 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #oncology #antineoplastics