Stevens-Johnson Syndrome: Causes, Diagnosis, Differentials, Symptoms and Treatment

Stevens-Johnson Syndrome (SJS) is a rare but serious type IV hypersensitivity reaction (subtype C) that affects the skin and mucous membranes. In this video, we break down the essential clinical features, pathophysiology, and histopathologic findings associated with SJS. Ideal for medical and nursing students, this lecture simplifies the condition for easier understanding and exam preparation. ✅ Key Topics Covered: What is Stevens-Johnson Syndrome? Prodromal symptoms: productive cough, headache, malaise, and arthralgia Skin and mucosal involvement Histopathologic features: full-thickness epidermal necrosis with minimal dermal infiltrate General approach to symptomatic management High-yield facts for USMLE and NCLEX exams ⚠️ SJS is a medical emergency that requires early recognition and supportive care.