BIONIC: Non-Invasive Brain Stimulation and Monitoring

In this talk, Dr. Brian Lundstrom explores how non‑invasive brain stimulation—including transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)—is reshaping the way clinicians understand and treat neurological hyper‑excitability disorders, especially epilepsy. He shares real patient cases demonstrating how these techniques can reduce seizures, avoid systemic medication side effects, and provide new therapeutic options where surgery or medications fall short. Dr. Lundstrom also explains how EEG, invasive recordings, and increasingly MEG can reveal hidden patterns of brain excitability and guide more precise interventions. Using bottom‑up computational models and neural biomarkers, his team is working to better understand why stimulation works—and how to tailor it for each patient. The talk looks ahead to a future where brain stimulation is safer, more personalized, and potentially disease‑modifying, offering new hope for patients with epilepsy and other neurological conditions driven by abnormal brain activity. 00:00 Introduction to Dr. Brian Lundstrom 00:49 Background, Training & Early Career 01:56 Patient Case: Severe Hyper‑Excitability on EEG 03:17 Medication Limits & Need for Better Approaches 04:28 Bioelectronics as the “Third Pillar” of Medicine 05:13 Invasive EEG & Understanding Brain Hyper‑Excitability 06:25 Non‑Invasive Brain Stimulation: TMS & tDCS 08:23 Clinical Impact: Real‑World TMS/TDCs Case Reducing Seizures 10:23 Biomarkers, Modeling & Advances in MEG for Targeting 15:05 Future Vision: Personalized, Optimized Brain Stimulation