AUA2025: Chemotherapy and Immunotherapy for Urologists and Advanced Practice Providers (APPs) CME Available: https://auau.auanet.org/node/43009 At the conclusion of this activity, participants will be able to: 1. Identify the guidelines for first-line and beyond treatment of patients with hormone-sensitive advanced and metastatic prostate cancer, including medications, their mechanism, side effects and efficacy. 2. Summarize the recommendations for first-line and beyond treatment of castrate-resistant metastatic and nonmetastatic prostate cancer, including medications, their mechanism, side effects and efficacy. 3. Diagram the treatment options for high-risk non-muscle invasive bladder cancer. 4. Distinguish the guideline-defined therapeutic options for locally advanced and metastatic bladder cancer. 5. Discuss treatment options for locally advanced and metastatic kidney cancer, including medications, their mechanism, side effects and efficacy. ACKNOWLEDGEMENTS: This educational activity is supported by independent educational grants from: Astellas, Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC, Lantheus Medical Imaging, Novartis Pharmaceuticals Corporation, Pfizer, Inc.

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